Wired Science Space Photo of the Day: Hourglass Nebula

This Hubble telescope snapshot of MyCn18, a young planetary nebula, reveals that the object has an hourglass shape with an intricate pattern of "etchings" in its walls. A planetary nebula is the glowing relic of a dying, Sun-like star.

The results are of great interest because they shed new light on the poorly understood ejection of stellar matter that accompanies the slow death of Sun-like stars. According to one theory on the formation of planetary nebulae, the hourglass shape is produced by the expansion of a fast stellar wind within a slowly expanding cloud, which is denser near its equator than near its poles.

Image: Raghvendra Sahai and John Trauger (JPL), the WFPC2 science team, and NASA [high-resolution]

Caption: Hubble Heritage site

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“Twilight Zone” reboot in the works from Bryan Singer, CBS Television Studios

LOS ANGELES (TheWrap.com) – Bryan Singer is about to enter “The Twilight Zone.”

The “X-Men” director is working on a reboot of Rod Serling‘s television series with CBS Television Studios, a spokeswoman for CBS Television Studios told TheWrap. Singer will develop and executive-produce the project, and could direct.

The project is currently in the very early stages.

The original “Twilight Zone” ran on CBS from 1959 to 1964, and the network revived the series in the 1980s. Most recently, the UPN ran a revival of the series, with Forest Whitaker hosting. That version, which launched in 2002, lasted one season.

Singer was also involved in the revival of another classic television series earlier this year, with NBC’s “The Munsters” revamp, dubbed “Mockingbird Lane.” Initially conceived as a series, “Mockingbird Lane” aired as a Halloween special for the network.

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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

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This bus' next stop: doing good

Maybe you want to help others. Maybe you long to lend a hand. But you're not sure where and you're not sure how and you don't know who to call.

You could ask around. Or you could book a seat on the Do Good Bus.

You will pay $25. You will get a box lunch. You will put yourself in the hands of a stranger.

When the bus takes off, you will not know where you are going — only that when you get there, you will be put to work.

You find yourself on this weekday afternoon one of an eclectic group, gathered a little shyly on an East Hollywood curb.

There's a Yelp marketer, a grad student, an actor, a novelist, a Manhattan Beach mother with her son and daughter, who just got home from prep school and college.

You see a school bus pull up. You step on board. It feels nostalgic, like day camp or a field trip.

Rebecca Pontius welcomes you, wearing jeans and sneakers and a black fleece vest. She looks like the kind of person who would plunge her hands deep into dirt, who wouldn't be afraid of the worms, who could lead you boldly.

The bus takes off, and Pontius stands toward the front, sure-footed. She founded the Do Good Bus, she tells you, to 1) build awareness, 2) build community, 3) encourage continued engagement.

Oh, she says, and to 3a) have fun. Hence the element of mystery, the faux holly branches that decorate some of the rows of seats, the white felt reindeer antlers she's wearing on her head.

She smiles a wide, toothy smile that makes you automatically reciprocate.

So you go along when she asks you to play get-to-know-you games. Even though you're embarrassed, you don't object when she assigns you one of the 12 days of Christmas to sing and act out when it's your turn.

Everyone's singing and laughing as the bus fits-and-starts down the freeway.

Maids-a-milking, geese-a-laying, bus-a-exiting somewhere in South Los Angeles.

It stops outside a boxy blue building — the Challengers Boys and Girls Club — where, finally, Pontius tells you you'll be helping children in foster care build the bicycles that will be their Christmas gifts.

She did it last year, she says. It was great. And she's brought along some powder that turns into fake snow, which the kids will like.

You step inside a large gym, where nothing proceeds quite as expected.

It's the holiday season, so way too many volunteers have shown up. The singer Ne-Yo is coming to lead a toy giveaway. There's a whole roomful of presents the children can choose from, including pre-assembled bikes — which means no bikes will need to be built.

You stand and you sit and you wait. Then the kids come. You try to help where you can — making sure they get in the right lines, handing out raffle tickets.

You see their joy at getting gifts, which is nice. You're in a place you might not ordinarily be, which is interesting. And as the children head out, you offer them snow. You put the powder in their cupped hands. You add water. The white stuff grows and begins to look real. It's even cold.

It makes them go wide-eyed. It makes them laugh. And you feel such moments of simple happiness are something.

It's chilly as you wait to get back on the bus. You get in a group hug with your fellow bus riders, who seem like old friends.

On the trip back in the dark, Pontius plays Christmas music. She serves you eggnog in Mason jars.

And she says she's sorry your help wasn't more needed today.

She promises the January ride will be more hands-on.

Come or don't, she tells you. But whatever you do, find a way to do something.

nita.lelyveld@latimes.com

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Maker Mom Builds Cookie-Cutter Empire With 3-D Printers

Athey Moravetz is doing some tasty work with her 3-D printers.

The video game designer has worked on PlayStation games like Resistance Retribution and Uncharted Golden Abyss. She's also a self-described "jack-of-all-trades," skilled with 3-D modeling tools like Maya, and knows how to design compelling characters with them.

After having two children she decided to work from home, and in addition to keeping active in the computer graphics industry, she also created a wildly successful Etsy shop, where she sells 3-D printed cookie cutters based on nerd culture favorites Pokemon, Dr. Who and Super Mario Brothers.

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Crafters send mittens with a message to Newtown

“Chester Raccoon stood at the edge of the forest and cried. ‘I don’t want to go to school,’ he told his mother. ‘I want to stay home with you. I want to play with my friends. And play with my toys. And read my books. And swing on my swing. Please may I stay home with you?’” — “The Kissing Hand,” by Audrey Penn.

___

NEW YORK (AP) — Imagining the horror for Sandy Hook Elementary students when they walk into their new school for the first time, a Connecticut mom is relying on Chester of the children’s classic “The Kissing Hand” and the busy fingers of her fellow knitters to ease their way.

Kim Piscatelli of East Hampton, Conn., hit on the idea of sending a copy of the book for each of the kids and a pair of handmade mittens adorned with a heart in one palm, signifying the reassuring kiss left there by the mother of scared, sad Chester in the story written by Audrey Penn.

Piscatelli, a 40-minute drive from Newtown, sent out a call to her friends, who called on their friends. The project she thought up just Sunday spread quickly on Facebook and websites for knitters and crafters, with the first shipment of books and mittens scheduled to land in Newtown the first week of January.

“I thought, how are those families ever going to get back in a routine of sending their children to school? If there ever was a town that needed to know about that book, it was Newtown,” said an overwhelmed Piscatelli, who now has a warehouse stacked with 1,600 copies of the book and plenty of volunteers to sort, pack and ship.

Others are hurriedly making mittens, from California and Canada to Florida and the U.S. Virgin Islands, in time for the start of classes in a once-shuttered school in nearby Monroe. A knitters’ group in Georgia pulled an all-night “knitathon” for the cause, Piscatelli said.

The book’s publisher, Tanglewood Press, has donated the books, along with enough copies of a sequel dealing with Chester’s loss of a playmate for teachers to read aloud.

In “The Kissing Hand,” the tearful boy is heading off to school for the first time, but he begs his mother to stay home. She spreads his tiny fingers and kisses him square in the palm and tells him “whenever you feel lonely and need a little loving from home, just press your hand to your cheek and think, ‘Mommy loves you.’”

The story was first published in 1993 by the Child Welfare League of America, a Washington, D.C.-based coalition of agencies and organizations helping children at risk. Penn had tried and failed for years to get her story of Chester published, until a league official heard Penn read it and decided to take it on.

“At first, no bookstore, no wholesaler would carry it,” said Peggy Tierney, who worked at the league and took Penn with her after starting Tanglewood. “Then kindergarten teachers discovered it, word spread, people started going into stores trying to find copies, then everyone started carrying it, and by 1999 it was on the New York Times best-seller list.”

One of Piscatelli’s first stops in getting her mitten project off the ground was to contact Penn, who lives in Durham, N.C. She recalled reading the story to her own three kids when they were younger.

Penn, who lost a brother to drowning when she was 13, signed off on the combined book-mitten project as soon as Piscatelli contacted her.

“When I saw the news, my heart was just torn in half. I couldn’t breathe. I couldn’t breathe. Enough is enough is enough,” the writer said.

Penn’s 2009 sequel, called “Chester the Raccoon and the Acorn Full of Memories,” has Chester the boy raccoon working through the death of a friend, Skiddil Squirrel, who has an accident. Chester’s teacher tells his class Skiddil won’t return to school, so Chester and his mother venture to a butterfly pond where the squirrel loved to play to discover some acorns Skiddil left there have sprouted into young trees.

“I’ve been involved with so many parents who have lost children,” Penn said. “They just seem to reach out to me and say we love your book and your book has been a comfort.”

The writer hopes the children of Sandy Hook will “get a sense of some kind of security” from the mitten project. “They’ll have a way of keeping in tangible touch with someone at home, someone they feel very secure with.”

Meantime, Piscatelli and dozens of knitters who have contacted her through the project’s Facebook page are pressing on to get the books and mittens in the students’ hands. About 600 kids attended Sandy Hook when Lanza opened fire, but Piscatelli plans to share mittens and books with all the schoolchildren of Newtown.

“The original request was for hand-knit mittens with a heart knit in, embroidered on or sewn on,” she said. “The reality is we have people sewing polar fleece mittens, mittens made from recycled sweaters, store-bought mittens. Every pair of handmade or store-bought mittens will have a heart sewn on if it isn’t there when we receive them.”

Piscatelli has heard from other crafters who plan related Kissing Hand projects, including a group of schoolchildren in Mississippi making pillows.

“Everybody wants to help,” she said. “Everybody’s looking for some way to reach out.”

When a company called Oceanhouse Media learned of Piscatelli’s idea they released a digital version of “The Kissing Hand” early and free of cost in the iTunes app store. Piscatelli has also heard from the loved ones of grown-up volunteers on the ground in Newtown.

“I got a call from a woman who said my father is with the Red Cross,” Piscatelli said. “He’s a psychologist and is there now and I really think he needs a pair of Kissing Hand mittens.”

___

Follow Leanne Italie on Twitter at https://twitter.com/litalie

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Alabama to End Isolation of Inmates With H.I.V.

Jamie Martin/Associated Press

The H.I.V. ward of an Alabama women's prison in 2008. The state was ordered to stop segregating inmates with the virus.

A federal judge on Friday ordered Alabama to stop isolating prisoners with H.I.V.

Alabama is one of two states, along with South Carolina, where H.I.V.-positive inmates are housed in separate prisons, away from other inmates, in an attempt to reduce medical costs and stop the spread of the virus, which causes AIDS.

Judge Myron H. Thompson of the Middle District of Alabama ruled in favor of a group of inmates who argued in a class-action lawsuit that they had been stigmatized and denied equal access to educational programs. The judge called the state’s policy “an unnecessary tool for preventing the transmission of H.I.V.” but “an effective one for humiliating and isolating prisoners living with the disease.”

After the AIDS epidemic of the 1980s, many states, including New York, quarantined H.I.V.-positive prisoners to prevent the virus from spreading through sexual contact or through blood when inmates tattooed one another. But most states ended the practice voluntarily as powerful antiretroviral drugs reduced the risk of transmission.

In Alabama, inmates are tested for H.I.V. when they enter prison. About 250 of the state’s 26,400 inmates have tested positive. They are housed in special dormitories at two prisons: one for men and one for women. No inmates have developed AIDS, the state says.

H.I.V.-positive inmates are treated differently from those with other viruses like hepatitis B and C, which are far more infectious, according to the World Health Organization. Inmates with H.I.V. are barred from eating in the cafeteria, working around food, enrolling in certain educational programs or transferring to prisons near their families.

Prisoners have been trying to overturn the policy for more than two decades. In 1995, a federal court upheld Alabama’s policy. Inmates filed the latest lawsuit last year.

“Today’s decision is historic,” said Margaret Winter, the associate director of the National Prison Project of the American Civil Liberties Union, which represented the inmates. “It spells an end to a segregation policy that has inflicted needless misery on Alabama prisoners with H.I.V. and their families.”

Brian Corbett, a spokesman for the Alabama Department of Corrections, said the state is “not prejudiced against H.I.V.-positive inmates” and has “worked hard over the years to improve their health care, living conditions and their activities.”

“We will continue our review of the court’s opinion and determine our next course of action in a timely manner,” he wrote.

During a monthlong trial in September, lawyers for the department argued that the policy improved the treatment of H.I.V.-positive inmates. Fewer doctors are needed if specialists in H.I.V. focus on 2 of the 29 state’s prisons.

The state spends an average of $22,000 per year on treating individual H.I.V.-positive inmates. The total is more than the cost of medicine for all other inmates, said Bill Lunsford, a lawyer for the Corrections Department.

South Carolina has also faced legal scrutiny. In 2010, the Justice Department notified the state that it was investigating the policy and might sue to overturn it.

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Boehner's 'fiscal cliff' plan fails

WASHINGTON — House Speaker John A. Boehner abruptly canceled a vote on his Plan B tax proposal late Thursday after failing to find enough GOP support, a stunning political defeat that effectively turned resolution of the year-end budget crisis over to President Obama and the Democrats.

The speaker had spent the last few weeks negotiating one-on-one with the president, establishing himself as the second-most powerful figure in Washington. But with his strategy imploding, Boehner conceded that he would play a lesser role.

"Now it is up to the president," he said, to work with a fellow Democrat, Senate Majority Leader Harry Reid of Nevada, "to avert the fiscal cliff."

The proposal the speaker had hoped to bring to a vote would have prevented a year-end tax increase for all but those earning more than $1 million a year.

But the Ohio Republican said in a statement, "It did not have sufficient support from our members to pass."

The unexpected turn of events caused an immediate reaction on Wall Street, where after-hours investors began to yank money out of U.S. stocks. Futures that track the Standard & Poor's 500 fell 1.5%, and the Dow Jones industrial average dropped 1.6%.

Now, Obama faces a crucial test of his leadership, with little time left to craft a deal.

Obama's most recent offer is likely to be the starting point. He made a substantial concession: raising taxes only on household income above $400,000, rather than the $250,000 threshold he campaigned on for reelection.

As he pursues votes in Congress, the president will need to face down Democrats, particularly the liberal wing that may feel emboldened to demand that a deal be tilted toward their views — perhaps with additional spending on infrastructure or unemployment benefits.

Any compromise will need substantial Democratic support. Although the president needs the speaker to allow legislation to come to a vote in the GOP-controlled House, Boehner emerges in a weakened position and has little leverage to demand further concessions. His Senate counterpart, Mitch McConnell (R-Ky.), will need to decide whether to become a final line of defense against Obama or step aside for a Democratic-led plan.

"The president's main priority is to ensure that taxes don't go up on 98% of Americans and 97% of small businesses in just a few short days," White House Press Secretary Jay Carney said after Boehner canceled the vote. "The president will work with Congress to get this done, and we are hopeful that we will be able to find a bipartisan solution quickly."

Without a compromise, most Americans will see their taxes automatically rise and spending cuts ripple across the economy in the new year. The White House and the speaker had been closing in on a broad deficit-reduction deal to steer around the coming "fiscal cliff," but Boehner suddenly changed course this week to gauge the sentiment of House Republicans.

The support expressed by top Republicans for new taxes has cracked the party's anti-tax orthodoxy and opened the door to a compromise that would have been unthinkable before the November election.

Mindful that his own job as speaker comes up for a vote in two weeks, Boehner must make a difficult choice: whether to allow a plan to come to the House floor without support from his majority, or play a key role in sending the nation over the fiscal cliff and raising taxes on most Americans.

As the speaker and his lieutenants trolled for votes earlier Thursday, buttonholing lawmakers in scenes like those in the movie "Lincoln," Carney dismissed Boehner's Plan B as a "multi-day exercise in futility."

"Instead of taking the opportunity that was presented to them to continue to negotiate what could be a very helpful large deal for the American people, the Republicans in the House have decided to run down an alley that has no exit," he said.

Late in the evening, as the time for voting neared, the House took an unscheduled recess — a sign that the tally had come up short. With Democrats almost unanimously against the bill, Boehner could afford to lose only two dozen Republican defectors.

The speaker and his top lieutenants then convened a late-night meeting of rank-and-file lawmakers and announced they were pulling the bill.

"We don't have the votes," the speaker said, according to a lawmaker in the room.

Conservatives split over Plan B, complicating Boehner's quest. He received a major assist when anti-tax stalwart Grover Norquist's Americans for Tax Reform declared that the bill was a vote for lower taxes and did not violate the pledge most Republicans had signed not to raise taxes. But other leading conservative groups opposed it, including FreedomWorks, which is extremely influential with tea party supporters.

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Hard to Handle

The 2013 Mustang Shelby GT500 is many things: imposing, populist, expensive. It’s also the last car Carroll Shelby had a hand in building. And true to the legacy of the legendary racer and auto designer who helped define the modern sports car, the GT500 is a Mustang with more power than any sane individual needs.

Its 5.8-liter supercharged V8 puts out a massive manufacturer-claimed 662 horsepower and 631 pound-feet of torque. But as a couple independent dyno tests have proven, the torque is probably understated. Minutes after firing the Shelby up, I pulled onto the highway and, with the traction control on, I opened the throttle with moderate aggression. The tires spun in first gear, then again in second and third — the third time, at near triple digits.

Lesson one: this thing has wacky power.

Lesson one: This thing has wacky power. Lesson two: Make sure the Goodyear Eagle F1s are nice and warm before getting happy with the accelerator. In four days of driving the GT500 on the street, from highway blasts to back-road bombing runs, the car proved itself to be reliably grin-inducing. But the big Shelby never lets you forget that it always has more power than traction, and driving it well is an exercise in throttle management. Line up at the stop light next to any “fast car” you care to name, and you’ll laugh at the ease with which you blow its doors off. But just as often, you’ll be embarrassed by the fact that you went up in a cloud of smoke, unable to hook up all that torque.

Even if it’s a little too much for you to control, you’ll still be able to admire its looks. “Tough” is the adjective onlookers most often use when describing it, and the combination of the “Deep Impact Blue” paint job, the white racing stripe and the black wheels on the GT500 I steered is both handsome and assertive. Large Cobra badges grace the front quarter-panels, front intake and rear fascia, reminding everyone that this is no mere Mustang GT. The hood’s power bulge, wheel arches, rear spoiler and bisected front intakes (there is no grille) shout strength.

The muscle contained in the engine bay is ungodly. The 5.8-liter V8 has a supercharger that alone has a capacity of 2.3 liters, which is more displacement than early ’80s four-cylinder Mustangs. Torque is everywhere, with 395 pound-feet available just off idle at 1,000 rpm. Between 2,200 and 5,800, 95 percent of the 631 pound-feet is available. It all gets channeled to the Eagle F1s via a six-speed Tremec T6060 manual and limited slip differential with a carbon fiber driveshaft in between. The SVT Performance Package that equipped our test car included staggered 19-inch front and 20-inch rear wheels of forged aluminum, Bilstein adjustable dampers, higher rate rear springs and a special instrument cluster and gear shift knob.

The instrument cluster includes a digital display between the speedometer and tach which not only shows the current calculated fuel efficiency (I saw about 14 mpg average) and gauge readings (including inlet and cylinder head temps), but a cool “track apps” summary with suspension and steering settings, launch control and traction control info. Supportive, comfortable Recaro bucket seats with shoulder-belt pass-throughs and racing stripe inserts keep the driver and passenger glued down.

Otherwise, the cockpit is straight-forward Mustang, including the Shaker audio system. Ford’s Sync Bluetooth is there, but no navigation or social media displays distract you.

If you’re a Mustang fan, you likely know the numbers by now, but repeating them for anyone who asks is half the fun of owning the 2013 GT500. It achieves 60 mph in approximately 3.5 seconds. The quarter-mile mark passes in 11.6 seconds at 125.7 mph, and the Shelby will do a legit 200 mph when pushed. Big 15-inch front discs and 12-inch rear discs with six-piston Brembo calipers stop the beast quickly too, halting it from 60 mph in about 102 feet.

That’s a lot of performance. That said, a driver of some ability can keep up on back roads in a car with half the horsepower. It’s not just that a public road prevents you from unleashing all the Shelby’s fury. Rather, as assiduously as Ford has worked to tame the GT500′s live-axle, Panhard-bar rear end, it still saps confidence by skittering over mid-corner bumps with the power on and exhibiting a tendency to axle hop under hard braking. Track testing has shown those brakes fade quickly, and you sense the fade on the street as well.

Thus, keeping the GT500 between the lines at speed requires concentration and quick hands. You do get electronic help. There’s adjustable effort steering on tap, as well as cockpit–adjustable suspension settings which sharpen the Shelby’s responses somewhat. On the other hand, it’s fun knowing that driving this Mustang must feel pretty much what driving a NASCAR Nationwide Series car is like. The exhaust soundtrack is appropriate, too — it sounds like a rolling kettle drum.

If you prefer the straighter lines of drag racing, the Shelby’s launch control, which allows you to set your launch rpm, is a truly useful electronic tool. Engage the control, put her in first, floor the throttle and let the clutch out. The Advance Trac stability system and traction control limit wheel-spin as you fly off the line. Don’t forget to upshift!

Advance Trac is useful in keeping you on the path while on the street, too — particularly on cold tires. The flip-side is that it works the brakes so hard you can quickly overheat them.

And that, as I mentioned, is key. Don’t get overheated with the Shelby or it might bite you. Respect the power and you’ll have a ball.

WIRED Tugboat-level power gives you acceleration wherever you want it. Surprisingly balanced chassis and steering with crisp turn-in work. Looks like a total bully. A 200 mph Mustang.

TIRED Give it a little too much throttle with cold tires and you’ll be going up in smoke like Cheech and Chong. Enough vertical suspension movement to classify as “head-toss.” A $63,000 Mustang.

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Martha Raddatz, Hot Off Debate Performance, Promoted at ABC News

NEW YORK (TheWrap.com) – Martha Raddatz, widely praised for her moderation of the vice presidential debate in October, has been given an expanded role as ABC News’ chief global affairs correspondent. Jonathan Karl, meanwhile, will become the network’s new chief White House correspondent, filling the void left by Jake Tapper‘s exit to CNN.

Raddatz will replace Tapper as the primary substitute for George Stephanopoulos on “This Week” and will contribute regularly to the Sunday morning show’s roundtable. Karl will also serve as a substitute and regularly appear on the roundtable.

Tapper departed ABC in part because he has long been interested in hosting “This Week” full-time, but Stephanopoulos has no plans to give up the hosting job, a person familiar with the situation told TheWrap.

ABC News President Ben Sherwood announced the new assignments for Raddatz and Karl on Thursday, soon after CNN announced Tapper’s hiring.

Karl has investigated wasteful federal spending, covered elections, and served as the network’s senior national security correspondent.

Raddatz has reported from the Pentagon, the State Department, the White House, and from conflict zones worldwide, including Afghanistan and Iraq.

But she has been perhaps most celebrated for keeping the vice presidential debate between Joe Biden and Paul Ryan on course after the moderator of the first presidential debate, Jim Lehrer, was accused of letting the candidates run amok.

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